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Shijun Wen Selected Research

platinum 109

4/2022PT109, a novel multi-kinase inhibitor suppresses glioblastoma multiforme through cell reprogramming: Involvement of PTBP1/PKM1/2 pathway.
9/2020Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo.

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Shijun Wen Research Topics

Disease

22Neoplasms (Cancer)
04/2022 - 01/2013
7Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2022 - 01/2016
3Colorectal Neoplasms (Colorectal Cancer)
01/2021 - 11/2015
3Alzheimer Disease (Alzheimer's Disease)
09/2020 - 10/2013
3Leukemia
01/2020 - 01/2016
2Glioma (Gliomas)
04/2022 - 01/2020
2Glioblastoma (Glioblastoma Multiforme)
04/2022 - 01/2020
2Lymphoma (Lymphomas)
01/2021 - 01/2017
2Mitochondrial Diseases (Mitochondrial Disease)
01/2021 - 01/2017
2Colonic Neoplasms (Colon Cancer)
07/2019 - 01/2017
2Rheumatoid Arthritis
07/2019 - 01/2018
2Tuberculosis (Tuberculoses)
01/2016 - 07/2012
1Hematologic Neoplasms (Hematological Malignancy)
12/2022
1Ataxia Telangiectasia (Louis Bar Syndrome)
01/2021
1Breast Neoplasms (Breast Cancer)
01/2021
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2021
1Inflammation (Inflammations)
09/2020
1Pathologic Processes
09/2020
1Neuroinflammatory Diseases
09/2020
1Carcinogenesis
01/2020
1Hepatocellular Carcinoma (Hepatoma)
01/2020
1Glucosephosphate Dehydrogenase Deficiency
01/2019
1Adenocarcinoma of Lung
01/2017
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2017
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2017
1Neoplasm Metastasis (Metastasis)
01/2017
1Stomach Neoplasms (Stomach Cancer)
01/2016
1Toxoplasmosis
11/2014

Drug/Important Bio-Agent (IBA)

10Pharmaceutical PreparationsIBA
01/2021 - 07/2012
4Phosphotransferases (Kinase)IBA
04/2022 - 09/2020
3Lysine (L-Lysine)FDA Link
12/2022 - 01/2018
3Therapeutic UsesIBA
04/2022 - 06/2018
3Reactive Oxygen Species (Oxygen Radicals)IBA
01/2021 - 01/2013
3Auranofin (Ridaura)FDA Link
01/2020 - 01/2018
2Histones (Histone)IBA
12/2022 - 01/2018
2platinum 109IBA
04/2022 - 09/2020
2Aurora Kinase AIBA
01/2022 - 01/2021
2snake venom protein C activatorIBA
01/2022 - 01/2021
2Transcription Factors (Transcription Factor)IBA
01/2021 - 06/2018
2Proteins (Proteins, Gene)FDA Link
01/2021 - 01/2021
2Biological ProductsIBA
01/2020 - 06/2017
2EnzymesIBA
01/2019 - 06/2018
2Glutathione (Reduced Glutathione)IBA
06/2017 - 01/2017
1antiglomerular basement membrane antibodyIBA
04/2022
1alpha-hydroxyglutarateIBA
01/2022
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2022
18-hydroxyguanineIBA
01/2021
1MLN 8237IBA
01/2021
13- (1H- indazol- 5- yl)- N- propylimidazo(1,2- b)pyridazin- 6- amineIBA
01/2021
1Aconitate Hydratase (Aconitase)IBA
01/2021
1tazemetostatIBA
01/2021
1DNA (Deoxyribonucleic Acid)IBA
01/2021
1Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
01/2021
1LipidsIBA
01/2021
1Messenger RNA (mRNA)IBA
01/2021
1Stearoyl-CoA DesaturaseIBA
01/2021
1Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2021
1Citric Acid (Citrate)FDA LinkGeneric
01/2021
1Ataxia Telangiectasia Mutated ProteinsIBA
01/2021
1LipopolysaccharidesIBA
09/2020
1GlucocorticoidsIBA
09/2020
1Glycogen Synthase (Synthase I)IBA
09/2020
1protein kinase C gamma (PRKCG)IBA
09/2020
1SulfonamidesIBA
01/2020
1Tranylcypromine (Parnate)FDA LinkGeneric
01/2020
1Thioredoxin-Disulfide ReductaseIBA
01/2020
1rheinIBA
01/2020
1Drug CombinationsIBA
07/2019
1Celecoxib (Celebrex)FDA Link
07/2019
1Indicators and Reagents (Reagents)IBA
01/2019
1IsotopesIBA
01/2019
1AntioxidantsIBA
01/2019
1Sorafenib (BAY 43-9006)FDA Link
01/2019
1TransketolaseIBA
01/2019
1fms-Like Tyrosine Kinase 3IBA
01/2019
1salinomycinIBA
03/2018
1Enhancer of Zeste Homolog 2 ProteinIBA
01/2018
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
01/2018
1GoldIBA
01/2018
1phenethyl isothiocyanate (PEITC)IBA
06/2017
1PhalloidineIBA
01/2017
1CateninsIBA
01/2017
1Glutamine (L-Glutamine)FDA Link
01/2017
1Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA
01/2017
1Protein Isoforms (Isoforms)IBA
01/2017
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2017
1pantothenate synthetaseIBA
01/2016
1Tyrosine (L-Tyrosine)FDA Link
01/2016
1Tyrosine Kinase InhibitorsIBA
01/2016
1Fetal Proteins (Fetoprotein)IBA
01/2016
1BenzoxazolesIBA
12/2015
1Cystine (L-Cystine)IBA
11/2015
1PlatinumIBA
11/2015
1Sulfasalazine (Azulfidine)FDA LinkGeneric
11/2015
1Cisplatin (Platino)FDA LinkGeneric
11/2015
1BerberineIBA
02/2015
1Pyrimethamine (Daraprim)FDA Link
11/2014
1Electron Transport Complex I (NADH-CoQ Reductase)IBA
11/2013

Therapy/Procedure

6Therapeutics
01/2022 - 11/2015
2Drug Therapy (Chemotherapy)
01/2017 - 11/2015